Abstract
The anti-inflammatory potential of 26 neolignans (14 of the bicyclooctane-type and 12 of the benzofuran-type), isolated from three Lauraceae species (Pleurothyrium cinereum, Ocotea macrophylla and Nectandra amazonum), was evaluated in vitro through inhibition of COX-1, COX-2, 5-LOX and agonist-induced aggregation of rabbit platelets. Benzofuran neolignans were found to be selective COX-2 inhibitors, whereas bicyclooctane neolignans inhibit selectively the PAF-action as well as COX-1 and 5-LOX. The neolignan 9-nor-7,8-dehydro-isolicarin B 15 and cinerin C 7 were found to be the most potent COX-2 inhibitor and PAF-antagonist, respectively. Nectamazin C 10 exhibited dual 5-LOX/COX-2 inhibition.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cyclooxygenase 1 / drug effects
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Cyclooxygenase 2 / drug effects
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Cyclooxygenase Inhibitors / chemistry*
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Cyclooxygenase Inhibitors / isolation & purification
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Cyclooxygenase Inhibitors / pharmacology
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Lauraceae / chemistry*
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Lipoxygenase Inhibitors / chemistry*
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Lipoxygenase Inhibitors / isolation & purification
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Lipoxygenase Inhibitors / pharmacology
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Platelet Aggregation Inhibitors / chemistry*
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Platelet Aggregation Inhibitors / isolation & purification
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Platelet Aggregation Inhibitors / pharmacology
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Rabbits
Substances
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Cyclooxygenase Inhibitors
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Lipoxygenase Inhibitors
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Platelet Aggregation Inhibitors
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Cyclooxygenase 1
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Cyclooxygenase 2